Sure
Think about relationships. Sometimes when your going through a break up the other person may prey on your empathy by leveraging their suffering and making you feel like a bad person with the end goal of keeping you in their life.
Or think about a traffic ticket. Some people might choose to cry to leverage the cops empathy so they will not have to pay a traffic fine.
There is a genuine side to it and its something very natural in interactions but but when its done intentionally it bothers me because that person is basically using the fact you are a good person to hurt you and get what they want. When used in Mafia as a tactic it can be effective but I feel it overall drags your and others enjoyment down which is the entire point of playing for me. I will choose having a good time over taking a win any day.